LymphedemaV1, France, Analysis, bibRecord, 000328

Venous Malformation: update on etiopathogenesis, diagnosis & management

Identifieur interne : 000328 ( France/Analysis ); précédent : 000327; suivant : 000329

Venous Malformation: update on etiopathogenesis, diagnosis & management

Auteurs : Anne Dompmartin [France] ; Miikka Vikkula [Belgique] ; Laurence M. Boon [Belgique]

Source :

Phlebology / Venous Forum of the Royal Society of Medicine [ 0268-3555 ] ; 2010.

RBID : PMC:3132084

Abstract

The aim of this review was to discuss the current knowledge on etiopathogenesis, diagnosis and therapeutic management of venous malformations. Venous malformations (VMs) are slow-flow vascular anomalies. They are simple, sporadic or familial (cutaneo-mucosal venous malformation or glomuvenous malformations), combined (e.g. capillaro-venous, capillaro-lymphaticovenous malformations) or syndromic (Klippel-Trenaunay, Blue Rubber Bleb Naevus and Maffucci). Genetic studies have identified causes of familial forms and of 40% of sporadic VMs. Another diagnostic advancement is the identification of elevated D-dimer level as the first biomarker of venous malformations within vascular anomalies. Those associated with pain are often responsive to Low Molecular Weight Heparin which should also be used to avoid disseminated intravascular coagulopathy secondary to intervention, especially if fibrinogen level is low. Finally, development of a modified sclerosing agent, ethylcellulose–ethanol, has improved therapy. It is efficient and safe, and widens indications for sclerotherapy to sensitive and dangerous areas such as hands, feet and periocular area.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132084

DOI: 10.1258/phleb.2009.009041
PubMed: 20870869
PubMed Central: 3132084

Affiliations:

Links to Exploration step

PMC:3132084

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p id="P3">The aim of this review was to discuss the current knowledge on etiopathogenesis, diagnosis and therapeutic management of venous malformations. Venous malformations (VMs) are slow-flow vascular anomalies. They are simple, sporadic or familial (cutaneo-mucosal venous malformation or glomuvenous malformations), combined (e.g. capillaro-venous, capillaro-lymphaticovenous malformations) or syndromic (Klippel-Trenaunay, Blue Rubber Bleb Naevus and Maffucci). Genetic studies have identified causes of familial forms and of 40% of sporadic VMs. Another diagnostic advancement is the identification of elevated D-dimer level as the first biomarker of venous malformations within vascular anomalies. Those associated with pain are often responsive to Low Molecular Weight Heparin which should also be used to avoid disseminated intravascular coagulopathy secondary to intervention, especially if fibrinogen level is low. Finally, development of a modified sclerosing agent, ethylcellulose–ethanol, has improved therapy. It is efficient and safe, and widens indications for sclerotherapy to sensitive and dangerous areas such as hands, feet and periocular area.</p>
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Venous Malformation: update on etiopathogenesis, diagnosis & management

Venous Malformation: update on etiopathogenesis, diagnosis & management

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